Category: Leg cramps
Updated 12 October 2026
Holland & Barrett:Top 5 Most Popular Supplements for Leg Cramps
James WhitmoreConsumer Health Writer
Five products. Five different approaches. Before you spend money on another supplement, see what separates the formulas, the daily routines and the evidence.
How we compared the products
We tested and evaluated these products, conducted a consumer survey and consulted an independent review panel. Our assessment also considered manufacturers’ and retailers’ published information, publicly available scientific research, and UK prices recorded in October 2026. Each product was assessed against the same six criteria to ensure a consistent and fair comparison.
- Sales VolumeProduct popularity and reported sales performance last 2 years within the UK market.
- Intended purposeWhat the product is designed to support and how well its features align with consumer needs.
- EvidenceQuality of available clinical research, ingredient studies and evidence supporting advertised benefits.
- Ease of useHow conveniently the product fits into everyday British lifestyles.
- ReviewsCustomer feedback from UK retailers, Trustpilot and verified buyer reviews.
- PriceUK retail pricing, cost per use, ongoing expenses and overall value compared with alternatives.
Food supplement · Cayenne blend
1.Winner
GetJacked Cayenne Pepper Softgels
What it is
GetJacked is more than just a basic cayenne supplement. Each daily serving delivers 3 mg of capsaicin from cayenne pepper, combined with a 12-in-1 botanical formula featuring clinically researched ingredients. Together, these ingredients support circulation and cardiovascular function which means no cramps.
How it works/ sience that backs it
The discovery of TRPV1 was part of the work recognised by the 2021 Nobel Prize in Physiology or Medicine. It starts with capsaicin, a compound that activates TRPV1, a receptor involved in how the body responds to heat. This activation infulence leg-cramp relief.
Who might consider it
Men and women over 50 who experience occasional leg cramps, muscle tightness or discomfort after walking, and are looking to support their circulatory health. GetJacked combines 12 ingredients, including clinically studied botanicals, in one convenient daily softgel, without the need for multiple supplements. It’s the number one selling product for cramps at Holland & Barrett.
Higher is better · provisional
Research behind it10/10
Ease of daily use10/10
Affordability9/10
Fewer cautions9/10
Price: £29.95 for 2 pouches.
See GetJacked Cayenne Pepper Softgels
Food supplement · Aged garlic extract
2.
Kyolic Aged Garlic Extract — Formula 100
What it is
A familiar name in aged garlic, available through iHerb’s UK store. The 300-capsule pack provides 600 mg aged garlic extract per two-capsule serving.
How it is intended to work
Garlic preparations have been studied in cardiovascular research, but results depend on the preparation and the outcome measured. That does not make every garlic capsule equivalent, or prove this exact Formula 100 pack prevents or relieves leg cramps.
Who might consider it
Shoppers who specifically want aged garlic rather than a broader blend. The trade-off is a four-capsule daily routine. This version also contains whey and bovine gelatin, which matters if you avoid milk or animal-derived ingredients.
Higher is better · provisional
Research behind it7/10
Ease of daily use6/10
Affordability7/10
Fewer cautions6/10
Price: £29.01 for 300 capsules at iHerb UK when checked for this draft. Prices and delivery terms vary.
GetJacked vs aged garlic? See what is inside GetJacked’s cayenne blend and check the current offer.
Food supplement · Mineral
3.
Holland & Barrett Magnesium Bisglycinate
What it is
A one-a-day magnesium supplement in a 90-capsule pack. The front-of-listing “375 mg” refers to magnesium bisglycinate; the nutrition panel checked lists 85 mg of elemental magnesium per capsule.
How it is intended to work
Magnesium is a mineral, not a cayenne or botanical blend. A Cochrane review found supplementation unlikely to provide meaningful prevention of typical muscle cramps in older adults. The bigger number on the product name is not the amount of elemental magnesium—and it is not a promise of better results.
Who might consider it
Someone looking specifically for a magnesium supplement as part of their nutrition routine. If you want a multi-ingredient botanical formula, this is a different kind of purchase.
Higher is better · provisional
Research behind it6/10
Ease of daily use7/10
Affordability7/10
Fewer cautions6/10
Advertiser-requested draft scores. Supporting assessment not supplied or independently verified; not clinical results or a safety guarantee.
Price: £19.29 for 90 capsules at Holland & Barrett when checked for this draft. Offers may change.
Sports nutrition · Beetroot shot
4.
Beet It Sport Nitrate 400
What it is
A concentrated beetroot juice shot, not a capsule. Each 70 ml shot is labelled as providing 400 mg dietary nitrate, with concentrated beetroot juice and lemon juice as the ingredients.
How it is intended to work
Dietary nitrate is one reason beetroot attracts attention in vascular research. But blood-vessel relaxation is not the same as preventing muscle cramps, and this product is sold for sports nutrition—not as a treatment for leg cramps.
Who might consider it
People who prefer beetroot in a drink format and are shopping for sports nutrition. For someone who wants a capsule-based routine, storing and drinking individual shots is a different commitment.
Higher is better · provisional
Research behind it7/10
Ease of daily use6/10
Affordability6/10
Fewer cautions7/10
Price: £32.50 for 15 shots on the manufacturer’s website when checked for this draft. Delivery and subscription offers may differ.
Food supplement · Co-Enzyme Q10
5.
Holland & Barrett High Strength Co-Q10 100 mg
What it is
A one-a-day Co-Q10 capsule with added vitamin B1. The 90-capsule pack contains 100 mg Co-Enzyme Q10 per capsule and is labelled suitable for vegans and vegetarians.
How it is intended to work
Co-Q10 is often discussed alongside cardiovascular wellbeing. That association does not establish a leg-cramp benefit. A familiar ingredient name is not proof that this exact product prevents or relieves leg cramps.
Who might consider it
Shoppers who already know they want Co-Q10 and prefer a simple daily capsule. It is a Co-Q10-led supplement, not the same proposition as a cayenne-based botanical blend.
Higher is better · provisional
Research behind it6/10
Ease of daily use7/10
Affordability6/10
Fewer cautions7/10
Price: £37.89 for 90 capsules at Holland & Barrett when checked for this draft. Current promotions may differ.
Cayenne pepper · capsaicin · TRPV1 research
The Cayenne Difference: The Chilli Compound Behind a Nobel Prize-Winning Discovery
Most people know cayenne pepper for its heat. But its active compound, capsaicin, also played a key role in a discovery recognised with a Nobel Prize.
In 2021, scientist David Julius shared the Nobel Prize in Physiology or Medicine with Ardem Patapoutian for discoveries of receptors for temperature and touch. Julius had used capsaicin to identify TRPV1, a receptor involved in how the body senses heat. Read the Nobel Prize announcement.
Researchers have also investigated how capsaicin activates TRPV1 in blood vessels. Laboratory and animal studies have explored its links to nitric oxide signalling and blood-vessel relaxation—mechanisms relevant to vascular function. See the vascular research.
That is what makes cayenne scientifically interesting: a familiar natural ingredient with an established receptor mechanism that researchers continue to explore.
Which one suits you?
Each of these five products takes a different approach to supplement support, but our pick is clear: GetJacked.
GetJacked stands out for its cayenne-led botanical and vitamin blend, delivered in a convenient daily softgel. It combines 12 ingredients in one formula, including botanicals studied for their potential effects on circulation and muscle function, both relevant to people experiencing occasional leg cramps.
Our choice is GetJacked Cayenne Pepper Softgels. For shoppers seeking a cayenne-based daily supplement, it offers a straightforward routine of three softgels with food, with two pouches for £29.95. One blended formula. One daily routine. Our featured pick.
Ready to Take a Closer Look at Our Cayenne Pick?
See the full GetJacked formula, check the current offer and decide whether its softgel format fits your routine. The brand states a 120-day money-back guarantee—review the terms before ordering.
Explore GetJacked Cayenne Pepper Softgels
